Literature DB >> 12435714

Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells.

Alvaro Pascual1, Sofía Ballesta, Isabel García, Evelio J Perea.   

Abstract

The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ones in both types of cell. The uptake was rapid and not saturable and was affected by environmental temperature and cell viability. Linezolid showed slight intracellular activity against Staphylococcus epidermidis at high extracellular concentrations.

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Year:  2002        PMID： 12435714      PMCID： PMC132792          DOI： 10.1128/AAC.46.12.4013-4015.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

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3.  Fluorometric measurement of ofloxacin uptake by human polymorphonuclear leukocytes.

Authors:  A Pascual; I Garcia; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

Review 4.  Linezolid.

Authors:  G French
Journal:  Int J Clin Pract       Date:  2001 Jan-Feb       Impact factor: 2.503

5.  In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents.

Authors:  G E Zurenko; B H Yagi; R D Schaadt; J W Allison; J O Kilburn; S E Glickman; D K Hutchinson; M R Barbachyn; S J Brickner
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

6.  The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.

Authors:  S M Swaney; H Aoki; M C Ganoza; D L Shinabarger
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

7.  Clindamycin uptake by human neutrophils.

Authors:  M S Klempner; B Styrt
Journal:  J Infect Dis       Date:  1981-11       Impact factor: 5.226

8.  Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.

Authors:  S J Brickner; D K Hutchinson; M R Barbachyn; P R Manninen; D A Ulanowicz; S A Garmon; K C Grega; S K Hendges; D S Toops; C W Ford; G E Zurenko
Journal:  J Med Chem       Date:  1996-02-02       Impact factor: 7.446

9.  Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes.

Authors:  A Pascual; D Tsukayama; J Kovarik; G Gekker; P Peterson
Journal:  Eur J Clin Microbiol       Date:  1987-04       Impact factor: 3.267

Review 10.  Oxazolidinones: a review.

Authors:  D I Diekema; R N Jones
Journal:  Drugs       Date:  2000-01       Impact factor: 11.431
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  10 in total

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Review 4.  The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus.

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Review 5.  Pharmacokinetics and pharmacodynamics of antibacterial agents.

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6.  Pharmacokinetics and penetration of linezolid into inflamed soft tissue in diabetic foot infections.

Authors:  J Majcher-Peszynska; G Haase; M Sass; R Mundkowski; A Pietsch; S Klammt; W Schareck; B Drewelow
Journal:  Eur J Clin Pharmacol       Date:  2008-07-25       Impact factor: 2.953

Review 7.  Linezolid effects on bacterial toxin production and host immune response: review of the evidence.

Authors:  Binh An Diep; Ozlem Equils; David B Huang; Ron Gladue
Journal:  Curr Ther Res Clin Exp       Date:  2012-06

Review 8.  In vitro antibiotic activity against intraosteoblastic Staphylococcus aureus: a narrative review of the literature.

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9.  Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury.

Authors:  Stephen J Evans; Aled E L Roberts; Andrew Conway Morris; A John Simpson; Llinos G Harris; Dietrich Mack; Rowena E Jenkins; Thomas S Wilkinson
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10.  Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy.

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  10 in total

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