Unilateral "Page kidney" hypertension in man. Studies of the renin-angiotensin-aldosterone system before and after nephrectomy.

Hypertension developed in a 17-year-old boy one year after a flank injury. Intravenous pyelography showed a slightly smaller kidney on the injured side. Renal arteriography demonstrated unilateral decreased vascular filling. Renal vein ratios suggested an ischemic kidney, as did split-function studies. Nephrectomy cured the hypertension. Detailed studies before and after nephrectomy suggested that hyperactivity of the renin-angiotensin-aldosterone system may participate in the pathophysiology of this unusual cause of hypertension in man.