OBJECTIVE: To measure serum concentrations of elastin-derived peptides (S-EDP) in patients with aneurysmal, occlusive and ulcerative manifestations of atherosclerotic disease. MATERIALS AND METHODS: S-EDP concentrations were measured by a competitive enzyme-linked immunosorbent assay in 10 patients with infrarenal aneurysms 5cm in diameter (AAA), 10 patients with distal aortic occlusive disease (AOD), 10 patients with symptomatic carotid stenosis (>or=70%) and plaque ulceration (SCS) and a control group of 10 patients with no similar specific manifestations of atherosclerotic disease (NAM). RESULTS: S-EDP concentrations (median, range) were significantly higher in patients with AAA (42ng/ml, 35-52, p<0.001) and SCS (49ng/ml, 37-60, p<0.001) but not AOD (28ng/ml, 22-38, p=0.240) compared to NAM (26ng/ml, 19-36) patients. CONCLUSION: Increased concentrations of S-EDP were associated with aneurysmal and ulcerative, but not occlusive, manifestations of atherosclerosis.
OBJECTIVE: To measure serum concentrations of elastin-derived peptides (S-EDP) in patients with aneurysmal, occlusive and ulcerative manifestations of atherosclerotic disease. MATERIALS AND METHODS:S-EDP concentrations were measured by a competitive enzyme-linked immunosorbent assay in 10 patients with infrarenal aneurysms 5cm in diameter (AAA), 10 patients with distal aortic occlusive disease (AOD), 10 patients with symptomatic carotid stenosis (>or=70%) and plaque ulceration (SCS) and a control group of 10 patients with no similar specific manifestations of atherosclerotic disease (NAM). RESULTS:S-EDP concentrations (median, range) were significantly higher in patients with AAA (42ng/ml, 35-52, p<0.001) and SCS (49ng/ml, 37-60, p<0.001) but not AOD (28ng/ml, 22-38, p=0.240) compared to NAM (26ng/ml, 19-36) patients. CONCLUSION: Increased concentrations of S-EDP were associated with aneurysmal and ulcerative, but not occlusive, manifestations of atherosclerosis.
Authors: Matthew A Dale; Wanfen Xiong; Jeffrey S Carson; Melissa K Suh; Andrew D Karpisek; Trevor M Meisinger; George P Casale; B Timothy Baxter Journal: J Immunol Date: 2016-05-04 Impact factor: 5.422
Authors: Chuang Xu; Sean Hesselbacher; Chu-Lin Tsai; Ming Shan; Margaret Spitz; Michael Scheurer; Luz Roberts; Sarah Perusich; Nazanin Zarinkamar; Harvey Coxson; Natasha Krowchuk; David B Corry; Farrah Kheradmand Journal: Front Immunol Date: 2012-08-27 Impact factor: 7.561
Authors: Yoo Jin Hong; Jinhyun Kim; Bo Ram Oh; Yun Jong Lee; Eun Young Lee; Eun Bong Lee; Seung-Hyo Lee; Yeong Wook Song Journal: J Korean Med Sci Date: 2012-04-25 Impact factor: 2.153