Literature DB >> 12435047

Particle-mediated DNA vaccination of mice, monkeys and men: looking beyond the dogma.

Lendon G Payne1, Deborah H Fuller, Joel R Haynes.   

Abstract

Data generated in the early phases of experimentation in a new field of scientific exploration sometimes results in hasty conclusions about the generality of the data. To some degree, this has happened at least twice in the relatively new area of DNA immunization. Early data seemed to indicate firstly that particle-mediated epidermal DNA immunization induced predominantly Th2-type cellular immune responses, and secondly that DNA immunization was not very successful in humans. This review highlights the current body of data showing that particle-mediated DNA immunization is highly effective in the induction Th1-type responses and is an efficient method for inducing immune responses in humans.

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Year:  2002        PMID： 12435047

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  8 in total

1.  Conference report--adjuvants and delivery: improving on vaccine immunogenicity highlights from the viral vaccine meeting; October 25-28, 2003; Barcelona, Spain.

Authors:  Elena Armandola
Journal:  MedGenMed       Date:  2004-01-26

Review 2.  Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells.

Authors:  Shaw-Wei D Tsen; Augustine H Paik; Chien-Fu Hung; T-C Wu
Journal:  Expert Rev Vaccines       Date:  2007-04       Impact factor: 5.217

3.  DNA vaccines for cervical cancer.

Authors:  Chien-Fu Huang; Archana Monie; Wei-Hung Weng; Tc Wu
Journal:  Am J Transl Res       Date:  2010-01-02       Impact factor: 4.060

4.  Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice.

Authors:  Kevin S Goudy; Bo Wang; Roland Tisch
Journal:  Clin Immunol       Date:  2008-10       Impact factor: 3.969

Review 5.  DNA vaccines for cervical cancer: from bench to bedside.

Authors:  Chien-Fu Hung; Archana Monie; Ronald D Alvarez; T-C Wu
Journal:  Exp Mol Med       Date:  2007-12-31       Impact factor: 8.718

6.  Genetic immunization converts the trypanosoma cruzi B-Cell mitogen proline racemase to an effective immunogen.

Authors:  Marianne A Bryan; Karen A Norris
Journal:  Infect Immun       Date:  2009-11-16       Impact factor: 3.441

Review 7.  Therapeutic HPV DNA vaccines.

Authors:  Archana Monie; Shaw-Wei D Tsen; Chien-Fu Hung; T-C Wu
Journal:  Expert Rev Vaccines       Date:  2009-09       Impact factor: 5.217

8.  Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates.

Authors:  Merika T Koday; Jolie A Leonard; Paul Munson; Adriana Forero; Michael Koday; Debra L Bratt; James T Fuller; Robert Murnane; Shulin Qin; Todd A Reinhart; Karen Duus; Ilhem Messaoudi; Amy L Hartman; Kelly Stefano-Cole; Juliet Morrison; Michael G Katze; Deborah Heydenburg Fuller
Journal:  PLoS One       Date:  2017-12-21       Impact factor: 3.240
  8 in total

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