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Literature DB >> 12433041

Automation of [11C]acyl chloride syntheses using commercially available 11C-modules.

Mario Matarrese¹, Francesco Sudati, Dmitri Soloviev, Sergio Todde, Elia Anna Turolla, Marzia Galli Kienle, Ferruccio Fazio.

Abstract

In implementing published procedures for the incorporation of [11C]carbon dioxide on the immobilized Grignard reagents for the radiosynthesis of [11C]acyl chlorides, several modifications on a commercial PET tracer synthesizer module for 11C-methylations were made to obtain reliable and reproducible production processes for routine clinical applications. High yields of [carbonyl-11C]WAY-100635 and [11C]zofenoprilat were obtained via 11C-carboxylation using [carbonyl-11C]cyclohexanecarbonyl chloride and 2-methyl-[l-11C]acryloyl chloride prepared with the modified module.

Entities: Chemical

Year: 2002 PMID： 12433041 DOI： 10.1016/s0969-8043(02)00182-3

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

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Cited

3 in total

1. Divergent synthesis of organophosphate [¹¹C]VX- and [¹¹C]Sarin-surrogates from a common set of starting materials.

Authors: Thomas R Hayes; Joseph E Blecha; Charles M Thompson; John M Gerdes; Henry F VanBrocklin
Journal: Appl Radiat Isot Date: 2019-05-24 Impact factor: 1.513

2. "In-loop" [¹¹ C]CO₂ fixation: Prototype and proof of concept.

Authors: Kenneth Dahl; Thomas L Collier; Ran Cheng; Xiaofei Zhang; Oleg Sadovski; Steven H Liang; Neil Vasdev
Journal: J Labelled Comp Radiopharm Date: 2017-07-25 Impact factor: 1.921

3. Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

Authors: Christina Rami-Mark; Johanna Ungersboeck; Daniela Haeusler; Lukas Nics; Cecile Philippe; Markus Mitterhauser; Matthaeus Willeit; Rupert Lanzenberger; Georgios Karanikas; Wolfgang Wadsak
Journal: Appl Radiat Isot Date: 2013-08-03 Impact factor: 1.513

3 in total

Automation of [11C]acyl chloride syntheses using commercially available 11C-modules.

1. Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials.

2. "In-loop" [11 C]CO2 fixation: Prototype and proof of concept.

3. Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

1. Divergent synthesis of organophosphate [¹¹C]VX- and [¹¹C]Sarin-surrogates from a common set of starting materials.

2. "In-loop" [¹¹ C]CO₂ fixation: Prototype and proof of concept.