Literature DB >> 12431875

The comparison of in the vitro effect of imipenem or meropenem combined with ciprofloxacin or levofloxacin against multidrug-resistant Pseudomonas aeruginosa strains.

Ilknur Erdem1, Jale Kaynar-Tascioglu, Birsen Kaya, Pasa Goktas.   

Abstract

This study evaluated the in vitro effects of the combination of a carbapenem (imipenem or meropenem) with a quinolone (ciprofloxacin or levofloxacin) using a microbroth dilution chequerboard technique and multidrug-resistant Pseudomonas aeruginosa strains. The ciprofloxacin and meropenem combination was only synergistic against 2 strains (6.2%) and ciprofloxacin and imipenem against 1 strain (3.1%). Levofloxacin and imipenem or meropenem were not synergistic for against any strain. None of the combinations showed an antagonistic effect.

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Year:  2002        PMID： 12431875     DOI： 10.1016/s0924-8579(02)00192-9

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  4 in total

1.  Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients.

Authors:  Vanessa E Rees; Rajbharan Yadav; Kate E Rogers; Jürgen B Bulitta; Veronika Wirth; Antonio Oliver; John D Boyce; Anton Y Peleg; Roger L Nation; Cornelia B Landersdorfer
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

Review 2.  Current treatment of pseudomonal infections in the elderly.

Authors:  Georgios Pappas; Kaiti Saplaoura; Matthew E Falagas
Journal:  Drugs Aging       Date:  2009       Impact factor: 3.923

3.  Clinically Relevant Epithelial Lining Fluid Concentrations of Meropenem with Ciprofloxacin Provide Synergistic Killing and Resistance Suppression of Hypermutable Pseudomonas aeruginosa in a Dynamic Biofilm Model.

Authors:  Hajira Bilal; Phillip J Bergen; Jessica R Tait; Steven C Wallis; Anton Y Peleg; Jason A Roberts; Antonio Oliver; Roger L Nation; Cornelia B Landersdorfer
Journal:  Antimicrob Agents Chemother       Date:  2020-06-23       Impact factor: 5.191

Review 4.  Global Threat of Carbapenem-Resistant Gram-Negative Bacteria.

Authors:  Shio-Shin Jean; Dorji Harnod; Po-Ren Hsueh
Journal:  Front Cell Infect Microbiol       Date:  2022-03-15       Impact factor: 5.293
  4 in total

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