Relation between structure and cholinergic activity. II. Synthesis and muscarinic activity of some sulfur analogs of 2-methyl-4-trimethylammoniomethyl-1,3-dioxolane-iodide.

The synthesis of 2-methyl-5-trimethylammoniomethyl-1,3-oxathiolane and some homologs are described. The stereochemical aspects are discussed on the basis of the NMR-spectra. The muscarinic activity of the oxathiolane is compared with the activities of the corresponding dioxolane and dithiolane.