| Literature DB >> 12430480 |
Taisheng Huang1, Charlene C K Keh, Chao-Jun Li.
Abstract
A method for the synthesis of alpha-amino acid derivatives and amines is developed via a zinc-mediated conjugate addition reaction of alkyl halides to alpha-phthalimidoacrylate derivatives and nucleophilic addition to imines in the presence of NH4Cl in water. No reaction was observed in the absence of water.Entities:
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Year: 2002 PMID： 12430480 DOI： 10.1039/b204585k
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222