Literature DB >> 12430467

One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT.

Xiao Bin Sun1, Jian Xun Kang, Yu Fen Zhao.   

Abstract

A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.

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Year:  2002        PMID: 12430467     DOI: 10.1039/b207657h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates.

Authors:  Qi Sun; Jocelyn P Edathil; Runzhi Wu; Eric D Smidansky; Craig E Cameron; Blake R Peterson
Journal:  Org Lett       Date:  2008-04-08       Impact factor: 6.005

  1 in total

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