Literature DB >> 12430417

A flexible strategy for the divergent modification of pleuromutilin.

Eric Bacqué1, François Pautrat, Samir Z Zard.   

Abstract

The complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12.

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Year:  2002        PMID： 12430417     DOI： 10.1039/b206568a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Forging C(sp3)-C(sp3) Bonds with Carbon-Centered Radicals in the Synthesis of Complex Molecules.

Authors:  Spencer P Pitre; Nicholas A Weires; Larry E Overman
Journal:  J Am Chem Soc       Date:  2019-01-04       Impact factor: 15.419

2.  Synthesis and Biological Activity Evaluation of Novel Heterocyclic Pleuromutilin Derivatives.

Authors:  Yunpeng Yi; Yunxing Fu; Pengcheng Dong; Wenwen Qin; Yu Liu; Jiangping Liang; Ruofeng Shang
Journal:  Molecules       Date:  2017-06-15       Impact factor: 4.411

3.  Radical chain repair: The hydroalkylation of polysubstituted unactivated alkenes.

Authors:  Guillaume Povie; Sankar Rao Suravarapu; Martin Peter Bircher; Melinda Meyer Mojzes; Samuel Rieder; Philippe Renaud
Journal:  Sci Adv       Date:  2018-07-20       Impact factor: 14.136

4.  The Very First Modification of Pleuromutilin and Lefamulin by Photoinitiated Radical Addition Reactions-Synthesis and Antibacterial Studies.

Authors:  Son Thai Le; Dávid Páll; Erzsébet Rőth; Tuyen Tran; Nóra Debreczeni; Miklós Bege; Ilona Bereczki; Eszter Ostorházi; Márton Milánkovits; Pál Herczegh; Anikó Borbás; Magdolna Csávás
Journal:  Pharmaceutics       Date:  2021-11-28       Impact factor: 6.321
  4 in total

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