| Literature DB >> 1243024 |
J B Bream, H Lauener, C W Picard, G Scholtysik, T G White.
Abstract
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride [2,6-dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure-activity relationships in this class of compounds are discussed.Entities:
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Year: 1975 PMID： 1243024
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172