Literature DB >> 12429942

Mitotic regulation: the fine tuning of separase activity.

Ritu Agarwal1, Orna Cohen-Fix.   

Abstract

Mitotic progression requires the dissolution of cohesion between sister chromatids. Cohesion is dissolved by an essential protease known as separase. Separase is highly conserved throughout evolution and is subjected to multiple levels of regulation. Here we discuss recent studies that unravel several key mechanisms for regulating separase activity.

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Year:  2002        PMID： 12429942

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  3 in total

1.  DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase.

Authors:  Farokh Dotiwala; Vinay V Eapen; Jacob C Harrison; Ayelet Arbel-Eden; Vikram Ranade; Satoshi Yoshida; James E Haber
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-19       Impact factor: 11.205

2.  The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.

Authors:  Vladimir P Bermudez; Yoshimasa Maniwa; Inger Tappin; Keiko Ozato; Kyoko Yokomori; Jerard Hurwitz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-20       Impact factor: 11.205

3.  The budding yeast PP2ACdc55 protein phosphatase prevents the onset of anaphase in response to morphogenetic defects.

Authors:  Elena Chiroli; Valentina Rossio; Giovanna Lucchini; Simonetta Piatti
Journal:  J Cell Biol       Date:  2007-05-14       Impact factor: 10.539
  3 in total

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