PURPOSE: Although thalidomide (Thal) was introduced successfully in the treatment of multiple myeloma (MM), the optimal Thal dosage and schedule are still controversial. The aim of this study was to analyze whether the effect of Thal in MM is dose dependent and whether the outcome might be improved when the Thal dosage is adjusted to parameters reflecting body size. EXPERIMENTAL DESIGN: From December 1998 to March 2001, 83 patients with relapsed MM were enrolled in a clinical Phase II trial and treated with a maximum Thal dosage of 400 mg daily. We performed a retrospective analysis and studied the effect of the cumulative 3-month Thal dosage on progression-free survival and overall survival (OS) together with age and the pretreatment levels of beta2-microglobulin, C-reactive protein, albumin, and hemoglobin in a Cox regression model. RESULTS: After a median follow-up time of 17 months (range, 1-30 months), the estimated 12-month progression-free survival and OS were 45% (SE = 6%) and 86% (SE = 4%) for the whole patient group. After backward selection, hemoglobin (P = 0.002) and the cumulative 3-month Thal dosage (P = 0.002) were the remaining factors for OS. The effect on OS could not be improved when the cumulative 3-month Thal dosage was adjusted to parameters reflecting body size such as height, weight, body surface area, or body mass index in comparison with Thal alone. CONCLUSIONS: Our retrospective analysis demonstrates that the cumulative 3-month Thal dosage is one of the major prognostic factors for OS, supporting the hypothesis of a dose-dependent effect of Thal in relapsed MM.
PURPOSE: Although thalidomide (Thal) was introduced successfully in the treatment of multiple myeloma (MM), the optimal Thal dosage and schedule are still controversial. The aim of this study was to analyze whether the effect of Thal in MM is dose dependent and whether the outcome might be improved when the Thal dosage is adjusted to parameters reflecting body size. EXPERIMENTAL DESIGN: From December 1998 to March 2001, 83 patients with relapsed MM were enrolled in a clinical Phase II trial and treated with a maximum Thal dosage of 400 mg daily. We performed a retrospective analysis and studied the effect of the cumulative 3-month Thal dosage on progression-free survival and overall survival (OS) together with age and the pretreatment levels of beta2-microglobulin, C-reactive protein, albumin, and hemoglobin in a Cox regression model. RESULTS: After a median follow-up time of 17 months (range, 1-30 months), the estimated 12-month progression-free survival and OS were 45% (SE = 6%) and 86% (SE = 4%) for the whole patient group. After backward selection, hemoglobin (P = 0.002) and the cumulative 3-month Thal dosage (P = 0.002) were the remaining factors for OS. The effect on OS could not be improved when the cumulative 3-month Thal dosage was adjusted to parameters reflecting body size such as height, weight, body surface area, or body mass index in comparison with Thal alone. CONCLUSIONS: Our retrospective analysis demonstrates that the cumulative 3-month Thal dosage is one of the major prognostic factors for OS, supporting the hypothesis of a dose-dependent effect of Thal in relapsed MM.
Authors: Martin Kropff; Honorata Giongco Baylon; Jens Hillengass; Tadeusz Robak; Roman Hajek; Peter Liebisch; Stefan Goranov; Cyrille Hulin; Joan Bladé; Tommaso Caravita; Herve Avet-Loiseau; Thomas M Moehler; Claire Pattou; Lela Lucy; Elisabeth Kueenburg; Axel Glasmacher; Robert Zerbib; Thierry Facon Journal: Haematologica Date: 2011-12-01 Impact factor: 9.941
Authors: Shaunna L Beedie; Cody J Peer; Steven Pisle; Erin R Gardner; Chris Mahony; Shelby Barnett; Agnieszka Ambrozak; Michael Gütschow; Cindy H Chau; Neil Vargesson; William D Figg Journal: Mol Cancer Ther Date: 2015-08-12 Impact factor: 6.261
Authors: J P Laubach; A Mahindra; C S Mitsiades; R L Schlossman; N C Munshi; I M Ghobrial; N Carreau; T Hideshima; K C Anderson; P G Richardson Journal: Leukemia Date: 2009-09-10 Impact factor: 11.528
Authors: I Hus; A Dmoszynska; J Manko; M Hus; D Jawniak; M Soroka-Wojtaszko; A Hellmann; H Ciepluch; A Skotnicki; T Wolska-Smolen; K Sulek; T Robak; L Konopka; J Kloczko Journal: Br J Cancer Date: 2004-11-29 Impact factor: 7.640