Literature DB >> 12429377

Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats.

Anthony E Kline1, Jianyun Yu, Jaime L Massucci, Ross D Zafonte, C Edward Dixon.   

Abstract

To further investigate the efficacy of 5-HT(1A) receptor agonism on functional and histological outcome in traumatically-brain injured (TBI) rats, a single intraperitoneal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.1, 0.5, or 1.0 mg/kg) or vehicle was given 15 min after controlled cortical impact or sham injury. Function was assessed by established motor and cognitive tests on post-operative days 1-5 and 14-18, respectively. Cortical lesion volume and hippocampal CA(1)/CA(3) cell survival were quantified at 4 weeks. The administration of 8-OH-DPAT (0.5 mg/kg) attenuated spatial acquisition deficits and reduced hippocampal CA(3) cell loss vs. vehicle (P < 0.05). These data augment published reports that 5-HT(1A) receptor agonists confer neuroprotective effects after experimental TBI. Copyright 2002 Elsevier Science Ireland Ltd.

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Year:  2002        PMID： 12429377     DOI： 10.1016/s0304-3940(02)01101-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  25 in total

1.  Evaluation of a combined treatment paradigm consisting of environmental enrichment and the 5-HT1A receptor agonist buspirone after experimental traumatic brain injury.

Authors:  Anthony E Kline; Adam S Olsen; Christopher N Sozda; Ann N Hoffman; Jeffrey P Cheng
Journal:  J Neurotrauma       Date:  2012-05-21       Impact factor: 5.269

2.  Traumatic brain injury-induced cognitive and histological deficits are attenuated by delayed and chronic treatment with the 5-HT1A-receptor agonist buspirone.

Authors:  Adam S Olsen; Christopher N Sozda; Jeffrey P Cheng; Ann N Hoffman; Anthony E Kline
Journal:  J Neurotrauma       Date:  2012-04-23       Impact factor: 5.269

Review 3.  A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury.

Authors:  Kevin W McConeghy; Jimmi Hatton; Lindsey Hughes; Aaron M Cook
Journal:  CNS Drugs       Date:  2012-07-01       Impact factor: 5.749

4.  Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury.

Authors:  Christopher N Sozda; Ann N Hoffman; Adam S Olsen; Jeffrey P Cheng; Ross D Zafonte; Anthony E Kline
Journal:  J Neurotrauma       Date:  2010-06       Impact factor: 5.269

5.  Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury.

Authors:  Benjamin Wells de Witt; Kathryn M Ehrenberg; Rose L McAloon; Amanda H Panos; Kaitlyn E Shaw; Priya V Raghavan; Elizabeth R Skidmore; Anthony E Kline
Journal:  Neurorehabil Neural Repair       Date:  2010-12-26       Impact factor: 3.919

6.  The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.

Authors:  Jeffrey P Cheng; Haris A Aslam; Ann N Hoffman; Ross D Zafonte; Anthony E Kline
Journal:  Neurosci Lett       Date:  2007-02-07       Impact factor: 3.046

7.  Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience.

Authors:  Ann N Hoffman; Rebecca R Malena; Brian P Westergom; Pallavi Luthra; Jeffrey P Cheng; Haris A Aslam; Ross D Zafonte; Anthony E Kline
Journal:  Neurosci Lett       Date:  2007-12-04       Impact factor: 3.046

Review 8.  Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.

Authors:  Corina O Bondi; Bridgette D Semple; Linda J Noble-Haeusslein; Nicole D Osier; Shaun W Carlson; C Edward Dixon; Christopher C Giza; Anthony E Kline
Journal:  Neurosci Biobehav Rev       Date:  2014-12-10       Impact factor: 8.989

9.  Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats.

Authors:  Kaitlyn E Shaw; Corina O Bondi; Samuel H Light; Lire A Massimino; Rose L McAloon; Christina M Monaco; Anthony E Kline
Journal:  J Neurotrauma       Date:  2013-03-26       Impact factor: 5.269

Review 10.  5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma.

Authors:  Jeffrey P Cheng; Jacob B Leary; Aerin Sembhi; Clarice M Edwards; Corina O Bondi; Anthony E Kline
Journal:  Brain Res       Date:  2015-11-21       Impact factor: 3.252
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