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Literature DB >> 12428807

Alpha-synuclein and presynaptic function: implications for Parkinson's disease.

Abstract

This article focuses on alpha-synuclein's role in normal and pathological axonal and presynaptic functions and its relationship to Parkinson's disease. It is not possible to mention all the contributions to aspects of this area. Readers interested in alpha-synuclein's relation to aggregation, Lewy lesions, and pathological modifications are referred to the many reviews (see Goldberg and Lansbury 2000; Galvin 2001a; Goedert 2001).

Entities: Disease Gene

Mesh：

Substances：

Year: 2002 PMID： 12428807 DOI： 10.1385/NMM:2:2:115

Source DB: PubMed Journal: Neuromolecular Med ISSN： 1535-1084 Impact factor: 3.843

98 in total

Review 1. Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded.

Authors: J P Julien
Journal: Cell Date: 2001-02-23 Impact factor: 41.582

2. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.

Authors: J E Galvin; K Uryu; V M Lee; J Q Trojanowski
Journal: Proc Natl Acad Sci U S A Date: 1999-11-09 Impact factor: 11.205

3. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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Journal: Neuron Date: 1995-08 Impact factor: 17.173

4. Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro.

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Journal: Neuroreport Date: 1999-03-17 Impact factor: 1.837

5. Retention and redistribution of proteins in mammalian nerve fibres by axoplasmic transport.

Authors: S Ochs
Journal: J Physiol Date: 1975-12 Impact factor: 5.182

6. Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.

Authors: P J McLean; H Kawamata; S Ribich; B T Hyman
Journal: J Biol Chem Date: 2000-03-24 Impact factor: 5.157

7. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine.

Authors: M J Nirenberg; J Chan; Y Liu; R H Edwards; V M Pickel
Journal: J Neurosci Date: 1996-07-01 Impact factor: 6.167

Review 8. Synucleinopathies: clinical and pathological implications.

Authors: J E Galvin; V M Lee; J Q Trojanowski
Journal: Arch Neurol Date: 2001-02

9. Identification of two distinct synucleins from human brain.

Authors: R Jakes; M G Spillantini; M Goedert
Journal: FEBS Lett Date: 1994-05-23 Impact factor: 4.124

10. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Authors: K Uéda; H Fukushima; E Masliah; Y Xia; A Iwai; M Yoshimoto; D A Otero; J Kondo; Y Ihara; T Saitoh
Journal: Proc Natl Acad Sci U S A Date: 1993-12-01 Impact factor: 11.205

13 in total

1. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.

Authors: Yaping Chu; Gerardo A Morfini; Lori B Langhamer; Yinzhen He; Scott T Brady; Jeffrey H Kordower
Journal: Brain Date: 2012-06-19 Impact factor: 13.501

2. RNA interference mediated silencing of alpha-synuclein in MN9D cells and its effects on cell viability.

Authors: Dong-Mei Liu; Ling Jin; Hao Wang; Huan-Ying Zhao; Chun-Li Zhao; Hui Yang
Journal: Neurosci Bull Date: 2008-04 Impact factor: 5.203

3. Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain.

Authors: Rachel Lowe; Dean L Pountney; Poul Henning Jensen; Wei Ping Gai; Nicolas H Voelcker
Journal: Protein Sci Date: 2004-11-10 Impact factor: 6.725

4. DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.

Authors: Sara Batelli; Diego Albani; Raffaela Rametta; Letizia Polito; Francesca Prato; Marzia Pesaresi; Alessandro Negro; Gianluigi Forloni
Journal: PLoS One Date: 2008-04-02 Impact factor: 3.240

Review 5. Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease.

Authors: Erika Guerrero; P Vasudevaraju; Muralidhar L Hegde; G B Britton; K S Rao
Journal: Mol Neurobiol Date: 2012-08-26 Impact factor: 5.590

6. Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).

Authors: S Batelli; E Peverelli; S Rodilossi; G Forloni; D Albani
Journal: Neuroscience Date: 2011-08-19 Impact factor: 3.590

Review 7. Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role.

Authors: Marco Emanuele; Evelina Chieregatti
Journal: Biomolecules Date: 2015-05-13

8. Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts.

Authors: Marco Emanuele; Alessandro Esposito; Serena Camerini; Flavia Antonucci; Silvia Ferrara; Silvia Seghezza; Tiziano Catelani; Marco Crescenzi; Roberto Marotta; Claudio Canale; Michela Matteoli; Elisabetta Menna; Evelina Chieregatti
Journal: EBioMedicine Date: 2016-04-05 Impact factor: 8.143

9. GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.

Authors: S Bellani; A Mescola; G Ronzitti; H Tsushima; S Tilve; C Canale; F Valtorta; E Chieregatti
Journal: Cell Death Differ Date: 2014-08-15 Impact factor: 15.828

10. Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells.

Authors: Dongmei Liu; Ling Jin; Hao Wang; Huanying Zhao; Chunli Zhao; Chunli Duan; Lingling Lu; Bo Wu; Shun Yu; Piu Chan; Yaohua Li; Hui Yang
Journal: Neurochem Res Date: 2008-03-21 Impact factor: 3.996