Literature DB >> 12426960

Toxicity to topical dimethyl sulfoxide (DMSO) when used as an extravasation antidote.

N Creus1, J Mateu, J Massó, C Codina, J Ribas.   

Abstract

DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is described. Furthermore, the increasing importance of DMSO pharmacology, as its use in haematologic patients is spreading, is reviewed.

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Year:  2002        PMID: 12426960     DOI: 10.1023/a:1020528203296

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN: 0928-1231


  5 in total

1.  Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants.

Authors:  M J Egorin; D M Rosen; R Sridhara; L Sensenbrenner; M Cottler-Fox
Journal:  J Clin Oncol       Date:  1998-02       Impact factor: 44.544

2.  Dimethylsulphoxide and cooling after extravasation of antitumour agents.

Authors:  G Bertelli; D Dini; G Forno; A Gozza; M Venturini; G Ballella; R Rosso
Journal:  Lancet       Date:  1993-04-24       Impact factor: 79.321

3.  Use of dimethyl sulfoxide in limiting tissue damage caused by extravasation of doxorubicin.

Authors:  I N Olver; M A Schwarz
Journal:  Cancer Treat Rep       Date:  1983-04

Review 4.  Antidotes to vesicant chemotherapy extravasations.

Authors:  R T Dorr
Journal:  Blood Rev       Date:  1990-03       Impact factor: 8.250

5.  A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation.

Authors:  I N Olver; J Aisner; A Hament; L Buchanan; J F Bishop; R S Kaplan
Journal:  J Clin Oncol       Date:  1988-11       Impact factor: 44.544

  5 in total
  2 in total

Review 1.  Treatment of anthracycline extravasations using dexrazoxane.

Authors:  D Conde-Estévez; J Mateu-de Antonio
Journal:  Clin Transl Oncol       Date:  2013-08-15       Impact factor: 3.405

2.  Toxic effects of dimethyl sulfoxide on red blood cells, platelets, and vascular endothelial cells in vitro.

Authors:  Xiaoyang Yi; Minxia Liu; Qun Luo; Hailong Zhuo; Hui Cao; Jiexi Wang; Ying Han
Journal:  FEBS Open Bio       Date:  2017-02-20       Impact factor: 2.693

  2 in total

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