| Literature DB >> 12426049 |
Mónica Diez-Ariza1, Mónica García-Alloza, Berta Lasheras, Joaquín Del Río, María Javier Ramírez.
Abstract
ACh release from the rat frontal cortex was increased by both local, 0.1-1 microM, and systemic, 0.1-10 microg/kg, administration of the 5-HT(3) receptor antagonist ondansetron, reaching a maximum peak of 143% over basal values. Bicuculline, 1-10 microM, and flumazenil, 5-10 mg/kg, antagonists at different sites of the GABA(A) receptor, also enhanced ACh release, with maximum effects of 85 and 124% above baseline, respectively. GABA(A) receptor antagonists potentiated the effect induced by ondansetron on ACh release, reaching a peak increase of 238% (with bicuculline) and 259% (with flumazenil) over basal levels. These results suggest an interaction of ondansetron with GABAergic neurons modulating ACh release in the rat frontal cortex in vivo.Entities:
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Year: 2002 PMID： 12426049 DOI： 10.1016/s0006-8993(02)03483-2
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252