OBJECTIVE: The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts. STUDY DESIGN: A meta-analysis of 8 population-based studies with information regarding live birth and oral clefts was performed. RESULTS: No association between increased maternal age and isolated oral clefts was found. CONCLUSION: Oral clefts occurrence is not correlated with increasing maternal age, and inclusion of data mixing isolated and syndromic cases can confound the analysis and must be avoided.
OBJECTIVE: The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts. STUDY DESIGN: A meta-analysis of 8 population-based studies with information regarding live birth and oral clefts was performed. RESULTS: No association between increased maternal age and isolated oral clefts was found. CONCLUSION:Oral clefts occurrence is not correlated with increasing maternal age, and inclusion of data mixing isolated and syndromic cases can confound the analysis and must be avoided.
Authors: Cara T Mai; Cynthia H Cassell; Robert E Meyer; Jennifer Isenburg; Mark A Canfield; Russel Rickard; Richard S Olney; Erin B Stallings; Meredith Beck; S Shahrukh Hashmi; Sook Ja Cho; Russell S Kirby Journal: Birth Defects Res A Clin Mol Teratol Date: 2014-11-14
Authors: V W Omo-Aghoja; L O Omo-Aghoja; V I Ugboko; O N Obuekwe; B D O Saheeb; P Feyi-Waboso; A Onowhakpor Journal: Afr Health Sci Date: 2010-03 Impact factor: 0.927
Authors: Li Dai; Jun Zhu; Meng Mao; Yanhua Li; Ying Deng; Yanping Wang; Juan Liang; Liu Tang; He Wang; Briseis A Kilfoy; Tongzhang Zheng; Yawei Zhang Journal: Birth Defects Res A Clin Mol Teratol Date: 2010-01
Authors: Aditi Jindal; Michelle McMeans; Somnya Narayanan; Erin K Rose; Shilpa Jain; Mary L Marazita; Renato Menezes; Ariadne Letra; Flavia M Carvalho; Carla A Brandon; Judith M Resick; Juan C Mereb; Fernando A Poletta; Jorge S Lopez-Camelo; Eduardo E Castilla; Iêda M Orioli; Alexandre R Vieira Journal: Int J Dent Date: 2011-06-08