Pharmacological study of a new substance, mecinarone.

Mecinarone, a benzofuranic chalcone, shows considerable vasodilating activity on the peripheral and cerebral circulation. The intramuscular irrigation is thus improved and the cerebral blood supply increased. This vasodilating activity is accompanied by only a slight drop in the systemic arterial pressure and occurs without cardiac depression. Mecinarone has also antibradykinin, antiserotonin and antiaggregation properties which added to the vasodilating activity, greatly increase its pharmacological interest.