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Literature DB >> 12423093

Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia.

Roger G Linington¹, Marilyn Robertson, Annick Gauthier, B Brett Finlay, Rob van Soest, Raymond J Andersen.

Abstract

Extracts of the marine sponge Caminus sphaeroconia showed potent activity in a screen for bacterial type III secretion inhibitors. Bioassay guided fractionation of the extract led to the isolation of the novel antimicrobial glycolipid caminoside A (1). The structure of caminoside A was elucidated by analysis of spectroscopic data and chemical degradation.[structure: see text]

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12423093 DOI： 10.1021/ol0268337

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

25 in total

1. Small-molecule inhibitors specifically targeting type III secretion.

Authors: R Nordfelth; A M Kauppi; H A Norberg; H Wolf-Watz; M Elofsson
Journal: Infect Immun Date: 2005-05 Impact factor: 3.441

2. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.

Authors: Annick Gauthier; Marilyn L Robertson; Michael Lowden; J Antonio Ibarra; José Luis Puente; B Brett Finlay
Journal: Antimicrob Agents Chemother Date: 2005-10 Impact factor: 5.191

Review 3. Marine pharmacology in 2001--2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action.

Authors: Alejandro M S Mayer; Mark T Hamann
Journal: Comp Biochem Physiol C Toxicol Pharmacol Date: 2005 Mar-Apr Impact factor: 3.228

Review 4. Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.

Authors: Eliana Alves; Marina Dias; Diana Lopes; Adelaide Almeida; Maria do Rosário Domingues; Felisa Rey
Journal: Antibiotics (Basel) Date: 2020-07-24

Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia.

1. Small-molecule inhibitors specifically targeting type III secretion.

2. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.

Review 4. Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.

Review 5. Possible drugs for the treatment of bacterial infections in the future: anti-virulence drugs.

Review 6. Chemical inhibitors of the type three secretion system: disarming bacterial pathogens.

7. The bacterial type III secretion system as a target for developing new antibiotics.

8. Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium.

9. An inhibitor of gram-negative bacterial virulence protein secretion.

10. Substituted 2-imino-5-arylidenethiazolidin-4-one inhibitors of bacterial type III secretion.