Literature DB >> 12421646

Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus.

Luigi Brunetti1, Lucia Recinella, Giustino Orlando, Barbara Michelotto, Chiara Di Nisio, Michele Vacca.   

Abstract

Ghrelin and amylin are gut-derived hormones that stimulate and inhibit food intake, respectively. Feeding is modulated by aminergic neurotransmitters in the hypothalamus. We have evaluated the effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release from rat hypothalamic synaptosomes. We found that ghrelin did not modify dopamine or norepinephrine release, but inhibited serotonin release. On the other hand, amylin inhibited dopamine release, without affecting norepinephrine or serotonin. We conclude that the appetite-stimulating activity of ghrelin could be mediated by inhibited serotonin release, while the anorectic effects of amylin could involve inhibited release of dopamine in the hypothalamus.

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Year:  2002        PMID： 12421646     DOI： 10.1016/s0014-2999(02)02552-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  22 in total

1.  Augmented cocaine conditioned place preference in rats pretreated with systemic ghrelin.

Authors:  Kristina W Davis; Paul J Wellman; P Shane Clifford
Journal:  Regul Pept       Date:  2007-01-24

Review 2.  Anorexia of aging and gut hormones.

Authors:  Deniz Atalayer; Nerys M Astbury
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Review 3.  Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa.

Authors:  Rachel A Ross; Yael Mandelblat-Cerf; Anne M J Verstegen
Journal:  Harv Rev Psychiatry       Date:  2016 Nov/Dec       Impact factor: 3.732

4.  Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.

Authors:  Harriët Schellekens; Wesley E P A van Oeffelen; Timothy G Dinan; John F Cryan
Journal:  J Biol Chem       Date:  2012-11-16       Impact factor: 5.157

5.  A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference.

Authors:  Sofie Gydesen; Sara Toftegaard Hjuler; Zenia Freving; Kim Vietz Andreassen; Nina Sonne; Lars I Hellgren; Morten Asser Karsdal; Kim Henriksen
Journal:  Br J Pharmacol       Date:  2017-02-15       Impact factor: 8.739

6.  A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder.

Authors:  Sara E Trace; Laura M Thornton; Jessica H Baker; Tammy L Root; Lauren E Janson; Paul Lichtenstein; Nancy L Pedersen; Cynthia M Bulik
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Review 7.  Current and potential roles of ghrelin in clinical practice.

Authors:  G Angelidis; V Valotassiou; P Georgoulias
Journal:  J Endocrinol Invest       Date:  2010-12       Impact factor: 4.256

Review 8.  The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders.

Authors:  Eva Maria Fritz; Nicolas Singewald; Dimitri De Bundel
Journal:  Front Synaptic Neurosci       Date:  2020-10-27

9.  Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats.

Authors:  Paul J Wellman; Chelsie N Hollas; Audrea E Elliott
Journal:  Regul Pept       Date:  2007-07-29

Review 10.  Critical determinants of hypothalamic appetitive neuropeptide development and expression: species considerations.

Authors:  B E Grayson; P Kievit; M S Smith; K L Grove
Journal:  Front Neuroendocrinol       Date:  2009-10-12       Impact factor: 8.606
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