OBJECTIVE: Nasopharyngeal colonization of Haemophilus influenzae (H. influenzae) in young children may be important in developing countries. METHOD: In this study, we screened school going children for carriage of H. influenzae. A total of 44 H. influenzae isolates out of a collection of 162 were characterized for biotypes, capsular serotypes and antibiotic resistance. RESULTS: A significant proportion of H. influenzae (25/44) isolates were serotype b. High antibiotic resistance was observed against commonly administered antibiotics like ampicillin (79%), chloramphenicol (20%), trimethoprim sulfamethoxazole (84%) and erythromycin (95%). Comparison of antibiotic resistance profile of nasopharyngeal isolates was observed to be correlated with those of H. influenzae from disease. CONCLUSION: Multidrug resistant nasopharyngeal H. influenzae in young healthy children may act as reservoir. Monitoring of antibiotic resistance among nasopharyngeal H. influenzae as a surrogate for invasive H. influenzae seems an attractive option.
OBJECTIVE: Nasopharyngeal colonization of Haemophilus influenzae (H. influenzae) in young children may be important in developing countries. METHOD: In this study, we screened school going children for carriage of H. influenzae. A total of 44 H. influenzae isolates out of a collection of 162 were characterized for biotypes, capsular serotypes and antibiotic resistance. RESULTS: A significant proportion of H. influenzae (25/44) isolates were serotype b. High antibiotic resistance was observed against commonly administered antibiotics like ampicillin (79%), chloramphenicol (20%), trimethoprim sulfamethoxazole (84%) and erythromycin (95%). Comparison of antibiotic resistance profile of nasopharyngeal isolates was observed to be correlated with those of H. influenzae from disease. CONCLUSION: Multidrug resistant nasopharyngeal H. influenzae in young healthy children may act as reservoir. Monitoring of antibiotic resistance among nasopharyngeal H. influenzae as a surrogate for invasive H. influenzae seems an attractive option.
Authors: D Acharya; A Desai; N Nanavaty; A Pandit; V Patel; J Shah; N Shendurnikar; S Singh; A Taneja; S Vani Journal: Indian Pediatr Date: 1995-10 Impact factor: 1.411
Authors: R Lagos; A Avendano; I Horwitz; J M Musser; S K Hoiseth; D R Maneval; M J Jones; M M Levine; J P Dattas; I Prenzel Journal: J Infect Dis Date: 1991-12 Impact factor: 5.226
Authors: Kandarpa K Saikia; Bimal K Das; Ramesh K Bewal; Arti Kapil; N K Arora; Seema Sood Journal: Indian J Med Res Date: 2012-11 Impact factor: 2.375
Authors: Richard A Adegbola; Rodrigo DeAntonio; Philip C Hill; Anna Roca; Effua Usuf; Bernard Hoet; Brian M Greenwood Journal: PLoS One Date: 2014-08-01 Impact factor: 3.240