Literature DB >> 12419387

Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives.

Neelam Bharti1, Kakul Husain, M T Gonzalez Garza, Delia E Cruz-Vega, J Castro-Garza, Benito D Mata-Cardenas, Fehmida Naqvi, Amir Azam.   

Abstract

Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

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Year:  2002        PMID： 12419387     DOI： 10.1016/s0960-894x(02)00703-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Condensed-phase relative Gibbs free energy and E/Z descriptors for 2-acetylthiophene and 2-acetylthiophene-N1-phenyl thiosemicarbazones.

Authors:  Alice L R Sales; Josué M Silla; Jonas L Neto; Cleber P A Anconi
Journal:  J Mol Model       Date:  2021-03-04       Impact factor: 1.810

2.  A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis.

Authors:  Shahram Solaymani-Mohammadi; Jeanine M Genkinger; Christopher A Loffredo; Steven M Singer
Journal:  PLoS Negl Trop Dis       Date:  2010-05-11

3.  Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans.

Authors:  Ximeng Duan; Zhiyu Xie; Liying Ma; Xueyang Jin; Ming Zhang; Yuliang Xu; Yue Liu; Hongxiang Lou; Wenqiang Chang
Journal:  Microbiol Spectr       Date:  2022-04-18

4.  Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells.

Authors:  Felipe S Pessoto; Cesar H Yokomizo; Tatiana Prieto; Cleverton S Fernandes; Alan P Silva; Carlos R Kaiser; Ernani A Basso; Iseli L Nantes
Journal:  Oxid Med Cell Longev       Date:  2015-05-05       Impact factor: 6.543

5.  Synthesis 1-acyl-3-(2'-aminophenyl) thioureas as anti-intestinal nematode prodrugs.

Authors:  Li-Ping Duan; Jia Xue; Li-Li Xu; Hao-Bing Zhang
Journal:  Molecules       Date:  2010-10-08       Impact factor: 4.411

6.  Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities.

Authors:  Ayşegül Karaküçük-İyidoğan; Demet Taşdemir; Emine Elçin Oruç-Emre; Jan Balzarini
Journal:  Eur J Med Chem       Date:  2011-10-01       Impact factor: 6.514

7.  Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis.

Authors:  Alexandra Ibáñez-Escribano; Cristina Fonseca-Berzal; Mónica Martínez-Montiel; Manuel Álvarez-Márquez; María Gómez-Núñez; Manuel Lacueva-Arnedo; Teresa Espinosa-Buitrago; Tania Martín-Pérez; José Antonio Escario; Penélope Merino-Montiel; Sara Montiel-Smith; Alicia Gómez-Barrio; Óscar López; José G Fernández-Bolaños
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

8.  Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons.

Authors:  Van Hien Pham; Thi Phuong Dung Phan; Dinh Chau Phan; Binh Duong Vu
Journal:  Molecules       Date:  2020-01-13       Impact factor: 4.411
  8 in total

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