| Literature DB >> 12419372 |
Lee Roy Morgan1, Branko S Jursic, Catherine L Hooper, Donna M Neumann, Kanappan Thangaraj, Blaise LeBlanc.
Abstract
The structure of the anticancer agent 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.Entities:
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Year: 2002 PMID： 12419372 DOI： 10.1016/s0960-894x(02)00725-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823