| Literature DB >> 12419364 |
Vishnu Vardhan Karnati1, Xingming Gao, Shouhai Gao, Wenqian Yang, Weijuan Ni, Sabapathy Sankar, Binghe Wang.
Abstract
A glucose selective diphenylboronic acid fluorescent sensor (10a) with a K(a) of 1472M(-1) has been synthesized and evaluated. This sensor shows a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity improvement for glucose over fructose is about 1400-fold compared with the monoboronic acid compound, phenylboronic acid. 1H NMR studies indicate that sensor 10a binds with alpha-D-glucofuranose in a bidentate manner (1:1 ratio).Entities:
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Year: 2002 PMID： 12419364 DOI： 10.1016/s0960-894x(02)00767-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823