| Literature DB >> 12419363 |
Dionisios Vourloumis1, Masayuki Takahashi, Geoffrey C Winters, Klaus B Simonsen, Benjamin K Ayida, Sofia Barluenga, Seema Qamar, Sarah Shandrick, Qiang Zhao, Thomas Hermann.
Abstract
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.Entities:
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Year: 2002 PMID： 12419363 DOI： 10.1016/s0960-894x(02)00759-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823