| Literature DB >> 12419361 |
Martin J Slater1, David M Andrews, Graham Baker, Susanne S Bethell, Seb Carey, Helene Chaignot, Berwyn Clarke, Barry Coomber, Malcolm Ellis, Andrew Good, Norman Gray, George Hardy, Paul Jones, Gail Mills, Ed Robinson.
Abstract
Using a pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a, with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, has an IC(50)=30 microM.Entities:
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Year: 2002 PMID： 12419361 DOI： 10.1016/s0960-894x(02)00789-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823