Literature DB >> 12419210

Deamidation of Bcl-X(L): a new twist in a genotoxic murder mystery.

Ricky W Johnstone1.   

Abstract

Bcl-2 proteins are critical regulators of apoptosis following DNA damage. Recent studies have shown that genotoxic stress induces the deamidation of Bcl-X(L), inhibiting its antiapoptotic activities. Remarkably, Rb and p53 are important regulators of this novel modification of Bcl-X(L).

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Year:  2002        PMID： 12419210     DOI： 10.1016/s1097-2765(02)00693-7

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  4 in total

1.  Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state.

Authors:  Bei Li; Richard L Schowen; Elizabeth M Topp; Ronald T Borchardt
Journal:  AAPS J       Date:  2006-03-20       Impact factor: 4.009

2.  A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death.

Authors:  Sheila J Semaan; Yan Li; Robert W Nickells
Journal:  ASN Neuro       Date:  2010-03-31       Impact factor: 4.146

3.  Biologically distinct conformations of Bcl-x can be resolved using 2D isoelectric focusing.

Authors:  Karen R Rockwell; Brigitte T Huber
Journal:  Mol Immunol       Date:  2009-03-27       Impact factor: 4.407

4.  Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment.

Authors:  Yu-Guo Yuan; Qiu-Ling Peng; Sangiliyandi Gurunathan
Journal:  Int J Nanomedicine       Date:  2017-09-05
  4 in total

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