BACKGROUND: Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancer patients with a family history (FH) of breast cancer. METHODS: Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0-II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method. RESULTS: The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21-88), with a median follow-up time of 8.8 years (range,.25-29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH. CONCLUSIONS: Breast-conservation therapy is not contraindicated in early-stage breast cancer patients with a positive FH.
BACKGROUND: Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancerpatients with a family history (FH) of breast cancer. METHODS: Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0-II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method. RESULTS: The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21-88), with a median follow-up time of 8.8 years (range,.25-29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH. CONCLUSIONS: Breast-conservation therapy is not contraindicated in early-stage breast cancerpatients with a positive FH.
Authors: Ellen T Chang; Roger L Milne; Kelly-Anne Phillips; Jane C Figueiredo; Meera Sangaramoorthy; Theresa H M Keegan; Irene L Andrulis; John L Hopper; Pamela J Goodwin; Frances P O'Malley; Nayana Weerasooriya; Carmel Apicella; Melissa C Southey; Michael L Friedlander; Graham G Giles; Alice S Whittemore; Dee W West; Esther M John Journal: Breast Cancer Res Treat Date: 2008-11-26 Impact factor: 4.872
Authors: H M Verkooijen; P O Chappuis; E Rapiti; G Vlastos; G Fioretta; S Sarp; A P Sappino; H Schubert; C Bouchardy Journal: Br J Cancer Date: 2006-01-30 Impact factor: 7.640