Quinacrine-induced psychiatric disturbances in a child with common variable immunodeficiency and chronic giardiasis.

Psychiatric disorders due to quinacrine for antiparasitic therapy represent an infrequent, but serious, complication. The remarkable course of a 12-year-old boy with common variable immunodeficiency who developed severe psychiatric reactions following quinacrine therapy for his resistant chronic giardiasis is presented. The broad clinical spectrum of quinacrine-associated neuropsychiatric disturbances has been emphasized for the clinicians. Copyright 2002 John Wiley & Sons, Ltd.