Literature DB >> 12414977

Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV.

Ulrike Schmidt1, Jörg Beyer, Ulf Polster, Laurel J Gershwin, Ursula J Buchholz.   

Abstract

Recombinant bovine respiratory syncytial virus (rBRSV) and an rBRSV deletion mutant lacking the G gene (rBRSVDeltaG) were characterized in calves with respect to replication competence, attenuation, and protective efficacy as live-attenuated BRSV vaccines. Both recombinant viruses were safe and induced protection against a BRSV challenge infection. rBRSV replicated efficiently in the upper respiratory tract. Intranasal immunization with rBRSVDeltaG led to infection but not to mucosal virus replication. Neutralizing antibodies were induced by rBRSV and rBRSVDeltaG. Thus, the BRSV attachment glycoprotein G seems to be dispensable in vaccinating calves against BRSV.

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Year:  2002        PMID： 12414977      PMCID： PMC136874          DOI： 10.1128/jvi.76.23.12355-12359.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

1.  Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene.

Authors:  S Techaarpornkul; N Barretto; M E Peeples
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

2.  Chimeric bovine respiratory syncytial virus with glycoprotein gene substitutions from human respiratory syncytial virus (HRSV): effects on host range and evaluation as a live-attenuated HRSV vaccine.

Authors:  U J Buchholz; H Granzow; K Schuldt; S S Whitehead; B R Murphy; P L Collins
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

3.  Efficacy of an inactivated respiratory syncytial virus vaccine in calves.

Authors:  J Ellis; K West; C Konoby; T Leard; G Gallo; J Conlon; N Fitzgerald
Journal:  J Am Vet Med Assoc       Date:  2001-06-15       Impact factor: 1.936

4.  CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.

Authors:  R A Tripp; L P Jones; L M Haynes; H Zheng; P M Murphy; L J Anderson
Journal:  Nat Immunol       Date:  2001-08       Impact factor: 25.606

Review 5.  Respiratory syncytial virus. Brief review.

Authors:  E J Stott; G Taylor
Journal:  Arch Virol       Date:  1985       Impact factor: 2.574

6.  Evolution of bovine respiratory syncytial virus.

Authors:  J F Valarcher; F Schelcher; H Bourhy
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

7.  Chimeric bovine respiratory syncytial virus with attachment and fusion glycoproteins replaced by bovine parainfluenza virus type 3 hemagglutinin-neuraminidase and fusion proteins.

Authors:  M B Stope; A Karger; U Schmidt; U J Buchholz
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

8.  Recombinant bovine respiratory syncytial virus with deletions of the G or SH genes: G and F proteins bind heparin.

Authors:  Axel Karger; Ulrike Schmidt; Ursula J Buchholz
Journal:  J Gen Virol       Date:  2001-03       Impact factor: 3.891

9.  Respiratory syncytial virus infection in mice.

Authors:  G Taylor; E J Stott; M Hughes; A P Collins
Journal:  Infect Immun       Date:  1984-02       Impact factor: 3.441

10.  Bovine respiratory syncytial virus (BRSV) pneumonia in beef calf herds despite vaccination.

Authors:  L E Larsen; C Tegtmeier; E Pedersen
Journal:  Acta Vet Scand       Date:  2001       Impact factor: 1.695
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  16 in total

1.  Characterization of human metapneumovirus F protein-promoted membrane fusion: critical roles for proteolytic processing and low pH.

Authors:  Rachel M Schowalter; Stacy E Smith; Rebecca Ellis Dutch
Journal:  J Virol       Date:  2006-09-13       Impact factor: 5.103

2.  Insertion of the two cleavage sites of the respiratory syncytial virus fusion protein in Sendai virus fusion protein leads to enhanced cell-cell fusion and a decreased dependency on the HN attachment protein for activity.

Authors:  Joanna Rawling; Blanca García-Barreno; José A Melero
Journal:  J Virol       Date:  2008-04-02       Impact factor: 5.103

3.  Recombinant Sendai viruses expressing fusion proteins with two furin cleavage sites mimic the syncytial and receptor-independent infection properties of respiratory syncytial virus.

Authors:  Joanna Rawling; Olga Cano; Dominique Garcin; Daniel Kolakofsky; José A Melero
Journal:  J Virol       Date:  2011-01-12       Impact factor: 5.103

4.  Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates.

Authors:  Stéphane Biacchesi; Quynh N Pham; Mario H Skiadopoulos; Brian R Murphy; Peter L Collins; Ursula J Buchholz
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

Review 5.  Animal pneumoviruses: molecular genetics and pathogenesis.

Authors:  Andrew J Easton; Joseph B Domachowske; Helene F Rosenberg
Journal:  Clin Microbiol Rev       Date:  2004-04       Impact factor: 26.132

6.  A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats.

Authors:  Myra N Widjojoatmodjo; Jolande Boes; Marleen van Bers; Yvonne van Remmerden; Paul J M Roholl; Willem Luytjes
Journal:  Virol J       Date:  2010-06-02       Impact factor: 4.099

7.  Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins.

Authors:  Jean-Francois Valarcher; Julie Furze; Sara Wyld; Roy Cook; Karl-Klaus Conzelmann; Geraldine Taylor
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

8.  Identification of a novel virulence factor in recombinant pneumonia virus of mice.

Authors:  Christine D Krempl; Anna Wnekowicz; Elaine W Lamirande; Giw Nayebagha; Peter L Collins; Ursula J Buchholz
Journal:  J Virol       Date:  2007-06-13       Impact factor: 5.103

9.  Low-pH triggering of human metapneumovirus fusion: essential residues and importance in entry.

Authors:  Rachel M Schowalter; Andres Chang; Jessica G Robach; Ursula J Buchholz; Rebecca Ellis Dutch
Journal:  J Virol       Date:  2008-11-26       Impact factor: 5.103

10.  A single vaccination with an inactivated bovine respiratory syncytial virus vaccine primes the cellular immune response in calves with maternal antibody.

Authors:  Mirjam T W van der Sluijs; Eva M Kuhn; Birgit Makoschey
Journal:  BMC Vet Res       Date:  2010-01-11       Impact factor: 2.741
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