Literature DB >> 12414784

Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.

Arnon P Kater1, Maikel P Peppelenbosch, Dees P M Brandjes, Mika Lumbantobing.   

Abstract

Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.

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Year:  2002        PMID： 12414784      PMCID： PMC130100          DOI： 10.1128/cdli.9.6.1396-1397.2002

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  6 in total

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