Literature DB >> 1241445

Voluntary morphine ingestion, morphine dependence, and recovery from withdrawal signs.

K A Khavari, T C Peters, P L Baity, A S Wilson.   

Abstract

We are reporting on conditions (without forced drinking or premedications) where rats voluntarily drink high quantities of sucrose-morphine solutions in preference to water. The volume ingested is inversely related to the morphine concentration in the liquid. The morphine antagonist, nalorphine, produced a clear set of opiate withdrawal signs in these (voluntarily) morphine-drinking rats. The severity of withdrawal signs was a function of the amount of ingested morphine. The present finding is the first report to show that rats ingest high quantities of sucrose-morphine without premedication or forced hydration procedures.

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Year:  1975        PMID： 1241445     DOI： 10.1016/0091-3057(75)90022-2

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  10 in total

1.  The effect of housing and gender on preference for morphine-sucrose solutions in rats.

Authors:  P F Hadaway; B K Alexander; R B Coambs; B Beyerstein
Journal:  Psychopharmacology (Berl)       Date:  1979       Impact factor: 4.530

2.  Aversiveness of oral methadone in rats.

Authors:  R E Chipkin; J A Rosecrans
Journal:  Psychopharmacology (Berl)       Date:  1978-05-31       Impact factor: 4.530

Review 3.  A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell.

Authors:  Daniel C Castro; Michael R Bruchas
Journal:  Neuron       Date:  2019-05-08       Impact factor: 17.173

4.  Morphine preference in individual rats after morphine ingestion.

Authors:  L Rönnbäck
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

5.  Voluntary consumption of morphine in 15 inbred mouse strains.

Authors:  J K Belknap; J C Crabbe; J Riggan; L A O'Toole
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  Behavioral intoxication following voluntary oral ingestion of tetramethylenedisulfotetramine: Dose-dependent onset, severity, survival, and recovery.

Authors:  Nathaniel C Rice; Noah A Rauscher; Jeffrey L Langston; Todd M Myers
Journal:  Neurotoxicology       Date:  2017-09-07       Impact factor: 4.294

7.  Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery.

Authors:  Nathaniel C Rice; Noah A Rauscher; Jeffrey L Langston; Todd M Myers
Journal:  Food Chem Toxicol       Date:  2018-02-16       Impact factor: 6.023

8.  Morphine ingestion: genetic control in mice.

Authors:  G P Horowitz; G Whitney; J C Smith; F K Stephan
Journal:  Psychopharmacology (Berl)       Date:  1977-04-29       Impact factor: 4.530

9.  Morphine withdrawal dramatically reduces lymphocytes in morphine-dependent macaques.

Authors:  Michael R Weed; Lucy M Carruth; Robert J Adams; Nancy A Ator; Robert D Hienz
Journal:  J Neuroimmune Pharmacol       Date:  2006-07-14       Impact factor: 4.147

10.  The effect of propranolol and midazolam on the reconsolidation of a morphine place preference in chronically treated rats.

Authors:  Michael J F Robinson; Michael Armson; Keith B J Franklin
Journal:  Front Behav Neurosci       Date:  2011-07-28       Impact factor: 3.558
  10 in total

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