| Literature DB >> 12413842 |
Uli Kazmaier1, Saskia Pähler, Rainer Endermann, Dieter Häbich, Hein-Peter Kroll, Bernd Riedl.
Abstract
Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure-activity relationship.Entities:
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Year: 2002 PMID： 12413842 DOI： 10.1016/s0968-0896(02)00317-6
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641