OBJECTIVES: To compare the extent of lipid peroxidation and the status of antioxidants in tumor and venous blood of patients with oral squamous cell carcinoma (OSCC) at different intraoral sites. DESIGN AND METHODS: Twenty four patients with OSCC at different intraoral sites and an equal number of age- and sex-matched reference subjects were chosen for the study. The concentrations of lipid peroxides and reduced glutathione (GSH) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were estimated in tissues and blood. RESULTS: Diminished lipid peroxidation in tumor tissue was accompanied by decreased activities of SOD and CAT with increase in GSH and GSH-dependent enzymes. In contrast, enhanced lipid peroxidation with decrease in antioxidants was observed in the venous blood of OSCC patients. CONCLUSION: No significant differences in lipid peroxidation and antioxidant levels were observed between patients with OSCC at different intraoral sites. However, our results revealed differences between the tumor and blood with respect to their susceptibility to lipid peroxidation and antioxidant status.
OBJECTIVES: To compare the extent of lipid peroxidation and the status of antioxidants in tumor and venous blood of patients with oral squamous cell carcinoma (OSCC) at different intraoral sites. DESIGN AND METHODS: Twenty four patients with OSCC at different intraoral sites and an equal number of age- and sex-matched reference subjects were chosen for the study. The concentrations of lipid peroxides and reduced glutathione (GSH) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were estimated in tissues and blood. RESULTS: Diminished lipid peroxidation in tumor tissue was accompanied by decreased activities of SOD and CAT with increase in GSH and GSH-dependent enzymes. In contrast, enhanced lipid peroxidation with decrease in antioxidants was observed in the venous blood of OSCC patients. CONCLUSION: No significant differences in lipid peroxidation and antioxidant levels were observed between patients with OSCC at different intraoral sites. However, our results revealed differences between the tumor and blood with respect to their susceptibility to lipid peroxidation and antioxidant status.
Authors: R K Jain; Gautam Bir Singh; Arvinder Pal Singh; R K Goel; N C Aryya; Sandeep K Jha Journal: Indian J Otolaryngol Head Neck Surg Date: 2011-05-17
Authors: John P Richie; Wayne Kleinman; Patricia Marina; Patricia Abraham; Ernst L Wynder; Joshua E Muscat Journal: Nutr Cancer Date: 2008 Impact factor: 2.900
Authors: Anissa Kaleemullah Shariff; Sangita R Patil; Pramod S Shukla; Ajit V Sontakke; Anup S Hendre; Anand K Gudur Journal: Indian J Clin Biochem Date: 2009-09-16
Authors: Teresa Stachowicz-Stencel; Anna Synakiewicz; Anna Owczarzak; Aleksandra Sliwinska; Wieslawa Lysiak-Szydlowska; Anna Balcerska Journal: Contemp Oncol (Pozn) Date: 2012-05-29