Literature DB >> 12413546

Glycosidase mechanisms.

Andrea Vasella1, Gideon J Davies, Matthias Böhm.   

Abstract

The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism. Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.

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Year:  2002        PMID： 12413546     DOI： 10.1016/s1367-5931(02)00380-0

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  48 in total

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2.  Crystal structures of Aspergillus japonicus fructosyltransferase complex with donor/acceptor substrates reveal complete subsites in the active site for catalysis.

Authors:  Phimonphan Chuankhayan; Chih-Yu Hsieh; Yen-Chieh Huang; Yi-You Hsieh; Hong-Hsiang Guan; Yin-Cheng Hsieh; Yueh-Chu Tien; Chung-De Chen; Chien-Min Chiang; Chun-Jung Chen
Journal:  J Biol Chem       Date:  2010-05-13       Impact factor: 5.157

3.  Free energy study of the catalytic mechanism of Trypanosoma cruzi trans-sialidase. From the Michaelis complex to the covalent intermediate.

Authors:  Gustavo Pierdominici-Sottile; Nicole A Horenstein; Adrian E Roitberg
Journal:  Biochemistry       Date:  2011-10-27       Impact factor: 3.162

4.  Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases.

Authors:  Susana Gonçalves; Nuno Borges; Ana M Esteves; Bruno L Victor; Cláudio M Soares; Helena Santos; Pedro M Matias
Journal:  J Biol Chem       Date:  2010-03-31       Impact factor: 5.157

5.  Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site.

Authors:  Louise L Major; Beata A Wolucka; James H Naismith
Journal:  J Am Chem Soc       Date:  2005-12-28       Impact factor: 15.419

6.  Crystal structure and snapshots along the reaction pathway of a family 51 alpha-L-arabinofuranosidase.

Authors:  Klaus Hövel; Dalia Shallom; Karsten Niefind; Valery Belakhov; Gil Shoham; Timor Baasov; Yuval Shoham; Dietmar Schomburg
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

7.  Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition.

Authors:  Yasin Pourfarjam; Jessica Ventura; Igor Kurinov; Ahra Cho; Joel Moss; In-Kwon Kim
Journal:  J Biol Chem       Date:  2018-06-15       Impact factor: 5.157

8.  Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases.

Authors:  Melanie A Higgins; Garrett E Whitworth; Nahida El Warry; Mialy Randriantsoa; Eric Samain; Robert D Burke; David J Vocadlo; Alisdair B Boraston
Journal:  J Biol Chem       Date:  2009-07-16       Impact factor: 5.157

9.  Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases.

Authors:  D Wade Abbott; Matthew S Macauley; David J Vocadlo; Alisdair B Boraston
Journal:  J Biol Chem       Date:  2009-01-30       Impact factor: 5.157

Review 10.  Glycosidase inhibition: assessing mimicry of the transition state.

Authors:  Tracey M Gloster; Gideon J Davies
Journal:  Org Biomol Chem       Date:  2009-11-05       Impact factor: 3.876
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