Literature DB >> 12413541

New reactions in clavulanic acid biosynthesis.

Craig A Townsend1.   

Abstract

Clavulanic acid is only a modestly effective antibiotic against bacterial infections in humans, but a potent inhibitor/inactivator of beta-lactamase enzymes that confer bacterial resistance. The biosynthetic pathway to clavulanic acid is considerably more complex than that to the structurally related penicillins and cephalosporins and has revealed several interesting reactions.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12413541     DOI： 10.1016/s1367-5931(02)00392-7

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  19 in total

1.  X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.

Authors:  Jonathan M Elkins; Nadia J Kershaw; Christopher J Schofield
Journal:  Biochem J       Date:  2005-01-15       Impact factor: 3.857

2.  Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.

Authors:  Nathan A Magarvey; Brad Haltli; Min He; Michael Greenstein; John A Hucul
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

3.  Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase.

Authors:  Mary L Raber; Michael F Freeman; Craig A Townsend
Journal:  J Biol Chem       Date:  2008-10-27       Impact factor: 5.157

4.  Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction.

Authors:  Ryotaro Hara; Kai Yamagata; Ryoma Miyake; Hiroshi Kawabata; Hisatoshi Uehara; Kuniki Kino
Journal:  Appl Environ Microbiol       Date:  2017-08-17       Impact factor: 4.792

5.  A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.

Authors:  Mary L Raber; Alvaro Castillo; Alexander Greer; Craig A Townsend
Journal:  Chembiochem       Date:  2009-12-14       Impact factor: 3.164

6.  Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB.

Authors:  Harriet L R Cooper; Girish Mishra; Xiongyi Huang; Marilla Pender-Cudlip; Rachel N Austin; John Shanklin; John T Groves
Journal:  J Am Chem Soc       Date:  2012-12-10       Impact factor: 15.419

Review 7.  Antibiotics from microbes: converging to kill.

Authors:  Michael A Fischbach
Journal:  Curr Opin Microbiol       Date:  2009-08-18       Impact factor: 7.934

8.  Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster.

Authors:  Michael G Thomas; Yolande A Chan; Sarah G Ozanick
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

9.  A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.

Authors:  Mary L Raber; Samantha O Arnett; Craig A Townsend
Journal:  Biochemistry       Date:  2009-06-09       Impact factor: 3.162

10.  Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase.

Authors:  Samantha O Arnett; Barbara Gerratana; Craig A Townsend
Journal:  Biochemistry       Date:  2007-07-21       Impact factor: 3.162
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.