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Literature DB >> 12413520

Present status on the genetic studies of asthma.

Abstract

Asthma, one of the most common chronic diseases, is a complex and heterogeneous disorder. The results of genome screens for asthma-related traits in 11 different populations identified at least 18 regions of the genome that probably house asthma/atopy genes. The most consistently replicated regions are on chromosomes 2q, 5q, 6p, 12q and 13q. Positional cloning projects are ongoing in laboratories around the world to identify the asthma susceptibility loci in these regions. In addition, many candidate genes have been associated with asthma phenotypes, such as the genes in the IL-4/IL-13 pathway.

Entities: Disease

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Year: 2002 PMID： 12413520 DOI： 10.1016/s0952-7915(02)00393-x

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

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Cited

31 in total

1. Population stratification confounds genetic association studies among Latinos.

Authors: Shweta Choudhry; Natasha E Coyle; Hua Tang; Keyan Salari; Denise Lind; Suzanne L Clark; Hui-Ju Tsai; Mariam Naqvi; Angie Phong; Ngim Ung; Henry Matallana; Pedro C Avila; Jesus Casal; Alfonso Torres; Sylvette Nazario; Richard Castro; Natalie C Battle; Eliseo J Perez-Stable; Pui-Yan Kwok; Dean Sheppard; Mark D Shriver; William Rodriguez-Cintron; Neil Risch; Elad Ziv; Esteban Gonzàlez Burchard
Journal: Hum Genet Date: 2005-11-08 Impact factor: 4.132

Review 2. Understanding genomics: implications for the emergency medicine physician and the treatment of asthma.

Authors: Robert J Freishtat; Stephen J Teach
Journal: Pediatr Emerg Care Date: 2006-01 Impact factor: 1.454

3. Quantitative linkage genome scan for atopy in a large collection of Caucasian families.

Authors: Bradley T Webb; Edwin van den Oord; Anthony Akkari; Steve Wilton; Tina Ly; Rachael Duff; Kathleen C Barnes; Karin Carlsen; Jorrit Gerritsen; Warren Lenney; Michael Silverman; Peter Sly; John Sundy; John Tsanakas; Andrea von Berg; Moira Whyte; Malcolm Blumenthal; Jorgen Vestbo; Lefkos Middleton; Peter J Helms; Wayne H Anderson; Sreekumar G Pillai
Journal: Hum Genet Date: 2006-11-14 Impact factor: 4.132

4. ORMDL3 gene is associated with asthma in three ethnically diverse populations.

Authors: Joshua Galanter; Shweta Choudhry; Celeste Eng; Sylvette Nazario; José R Rodríguez-Santana; Jesús Casal; Alfonso Torres-Palacios; Jorge Salas; Rocio Chapela; H Geoffrey Watson; Kelley Meade; Michael LeNoir; William Rodríguez-Cintrón; Pedro C Avila; Esteban González Burchard
Journal: Am J Respir Crit Care Med Date: 2008-02-28 Impact factor: 21.405

5. Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region.

Authors: Shweta Choudhry; Margaret Taub; Rui Mei; José Rodriguez-Santana; William Rodriguez-Cintron; Mark D Shriver; Elad Ziv; Neil J Risch; Esteban González Burchard
Journal: Hum Genet Date: 2008-04-10 Impact factor: 4.132

6. Allele-specific targeting of microRNAs to HLA-G and risk of asthma.

Authors: Zheng Tan; Glenn Randall; Jihua Fan; Blanca Camoretti-Mercado; Rebecca Brockman-Schneider; Lin Pan; Julian Solway; James E Gern; Robert F Lemanske; Dan Nicolae; Carole Ober
Journal: Am J Hum Genet Date: 2007-08-20 Impact factor: 11.025

7. Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma.

Authors: Petra Perin; Uroš Potočnik
Journal: Immunogenetics Date: 2014-01-10 Impact factor: 2.846