| Literature DB >> 12413258 |
R J Turner1, M Lambrost, C Holmes, S G Katz, C S Downs, D W Collins, S P Gatt.
Abstract
The volatile anaesthetic agents are known to influence uterine muscle tone. All of the agents studied to date have been found to produce uterine relaxation. This property has been used to produce therapeutic uterine relaxation for difficult obstetric deliveries and the Ex Utero Intrapartum Treatment (EXIT) procedure. This study describes the effects of sevoflurane on isolated human myometrium at concentrations of 0.1, 0.25, 0.5, 0.75, 1.0, 1.5, 2.5 and 3.5 MAC. Sevoflurane produces dose-dependent depression of uterine muscle contractility with an ED50 of 0.94 MAC. Frequency of contraction was increased at concentrations of 2.5 MAC and greater. At concentrations of 3.5 MAC and above, uterine activity was virtually abolished.Entities:
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Year: 2002 PMID： 12413258 DOI： 10.1177/0310057X0203000508
Source DB: PubMed Journal: Anaesth Intensive Care ISSN： 0310-057X Impact factor: 1.669