Literature DB >> 12412659

Derivation of a Monte Carlo method for modeling heterodyne detection in optical coherence tomography systems.

Andreas Tycho1, Thomas M Jørgensen, Harold T Yura, Peter E Andersen.   

Abstract

A Monte Carlo (MC) method for modeling optical coherence tomography (OCT) measurements of a diffusely reflecting discontinuity embedded in a scattering medium is presented. For the first time to the authors' knowledge it is shown analytically that the applicability of an MC approach to this optical geometry is firmly justified, because, as we show, in the conjugate image plane the field reflected from the sample is delta-correlated from which it follows that the heterodyne signal is calculated from the intensity distribution only. This is not a trivial result because, in general, the light from the sample will have a finite spatial coherence that cannot be accounted for by MC simulation. To estimate this intensity distribution adequately we have developed a novel method for modeling a focused Gaussian beam in MC simulation. This approach is valid for a softly as well as for a strongly focused beam, and it is shown that in free space the full three-dimensional intensity distribution of a Gaussian beam is obtained. The OCT signal and the intensity distribution in a scattering medium have been obtained for several geometries with the suggested MC method; when this model and a recently published analytical model based on the extended Huygens-Fresnel principle are compared, excellent agreement is found.

Mesh:

Year:  2002        PMID: 12412659     DOI: 10.1364/ao.41.006676

Source DB:  PubMed          Journal:  Appl Opt        ISSN: 1559-128X            Impact factor:   1.980


  9 in total

1.  Monte Carlo modeling of spatial coherence: free-space diffraction.

Authors:  David G Fischer; Scott A Prahl; Donald D Duncan
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2008-10       Impact factor: 2.129

2.  Maximum imaging depth of two-photon autofluorescence microscopy in epithelial tissues.

Authors:  Nicholas J Durr; Christian T Weisspfennig; Benjamin A Holfeld; Adela Ben-Yakar
Journal:  J Biomed Opt       Date:  2011-02       Impact factor: 3.170

3.  Effects of light scattering on optical-resolution photoacoustic microscopy.

Authors:  Yan Liu; Chi Zhang; Lihong V Wang
Journal:  J Biomed Opt       Date:  2012-12       Impact factor: 3.170

4.  Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry.

Authors:  Siyu Chen; Ji Yi; Wenzhong Liu; Vadim Backman; Hao F Zhang
Journal:  IEEE Trans Biomed Eng       Date:  2015-05-04       Impact factor: 4.538

5.  Approximate image synthesis in optical coherence tomography.

Authors:  Callum M Macdonald; Peter R T Munro
Journal:  Biomed Opt Express       Date:  2021-05-12       Impact factor: 3.732

6.  Confocal laser feedback tomography for skin cancer detection.

Authors:  Alireza Mowla; Benjamin Wensheng Du; Thomas Taimre; Karl Bertling; Stephen Wilson; H Peter Soyer; Aleksandar D Rakić
Journal:  Biomed Opt Express       Date:  2017-08-10       Impact factor: 3.732

7.  Electric field Monte Carlo simulations of focal field distributions produced by tightly focused laser beams in tissues.

Authors:  Carole K Hayakawa; Eric O Potma; Vasan Venugopalan
Journal:  Biomed Opt Express       Date:  2011-01-06       Impact factor: 3.732

8.  Concurrent Reflectance Confocal Microscopy and Laser Doppler Flowmetry to Improve Skin Cancer Imaging: A Monte Carlo Model and Experimental Validation.

Authors:  Alireza Mowla; Thomas Taimre; Yah Leng Lim; Karl Bertling; Stephen J Wilson; Tarl W Prow; H Peter Soyer; Aleksandar D Rakić
Journal:  Sensors (Basel)       Date:  2016-09-01       Impact factor: 3.576

9.  Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation.

Authors:  Paweł Ossowski; Andrea Curatolo; David D Sampson; Peter R T Munro
Journal:  Biomed Opt Express       Date:  2018-06-13       Impact factor: 3.732

  9 in total

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