BACKGROUND: Men with prostate carcinoma who are treated with androgen deprivation therapy (ADT) are reported to be at an increased risk of bone loss and weight changes due to the sudden disruption of hormonal levels. In the current case-control study, the authors examined the prevalence and magnitude of low bone density and obesity among men with prostate carcinoma who were treated with ADT. METHODS: Sixty-two men with prostate carcinoma who had been receiving ADT for 1-5 years were included as cases. Healthy men (n = 47) with a prostate specific antigen level < 4.0 ng/mL were recruited as controls. Body composition and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry. The average age was 74.3 years for the cases and 72.8 years for the controls. RESULTS: The results of the current study demonstrate that prostate carcinoma cases had significantly higher body weight (86.5 kg vs. 80.6 kg), a higher percentage of body fat (30% vs. 26%), and a lower total body BMD (1.12 mg/cm(2) vs. 1.17mg/ cm(2)) compared with controls (P < 0.05). Cases were more likely to be obese (27.4% vs 43%) and have low BMD at trochanter (32.3% vs. 10.6%), intertrochanter (48.4% vs. 29.8%), and total hip measurements (50.0% vs. 25.3%). CONCLUSIONS: The results of the current study indicate that men with prostate carcinoma who are treated with ADT have a significantly increased risk of low bone density and obesity. Copyright 2002 American Cancer Society.
BACKGROUND:Men with prostate carcinoma who are treated with androgen deprivation therapy (ADT) are reported to be at an increased risk of bone loss and weight changes due to the sudden disruption of hormonal levels. In the current case-control study, the authors examined the prevalence and magnitude of low bone density and obesity among men with prostate carcinoma who were treated with ADT. METHODS: Sixty-two men with prostate carcinoma who had been receiving ADT for 1-5 years were included as cases. Healthy men (n = 47) with a prostate specific antigen level < 4.0 ng/mL were recruited as controls. Body composition and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry. The average age was 74.3 years for the cases and 72.8 years for the controls. RESULTS: The results of the current study demonstrate that prostate carcinoma cases had significantly higher body weight (86.5 kg vs. 80.6 kg), a higher percentage of body fat (30% vs. 26%), and a lower total body BMD (1.12 mg/cm(2) vs. 1.17mg/ cm(2)) compared with controls (P < 0.05). Cases were more likely to be obese (27.4% vs 43%) and have low BMD at trochanter (32.3% vs. 10.6%), intertrochanter (48.4% vs. 29.8%), and total hip measurements (50.0% vs. 25.3%). CONCLUSIONS: The results of the current study indicate that men with prostate carcinoma who are treated with ADT have a significantly increased risk of low bone density and obesity. Copyright 2002 American Cancer Society.
Authors: Matthew J McHale; Zaheer U Sarwar; Damon P Cardenas; Laurel Porter; Anna S Salinas; Joel E Michalek; Linda M McManus; Paula K Shireman Journal: Am J Physiol Regul Integr Comp Physiol Date: 2011-11-23 Impact factor: 3.619
Authors: Annie-Claude M Lassemillante; Suhail A R Doi; John D Hooper; John B Prins; Olivia R L Wright Journal: Endocrine Date: 2013-10-31 Impact factor: 3.633
Authors: Angela S Alberga; Roanne J Segal; Robert D Reid; Chris G Scott; Ronald J Sigal; Farah Khandwala; James Jaffey; George A Wells; Glen P Kenny Journal: Support Care Cancer Date: 2011-05-03 Impact factor: 3.603
Authors: Kozhaya N Mallah; Christopher J DiBlasio; Audrey C Rhee; Peter T Scardino; Michael W Kattan Journal: Cancer Date: 2005-05-15 Impact factor: 6.860
Authors: Ary Serpa Neto; Marcos Tobias-Machado; Marcos A P Esteves; Marília D Senra; Marcelo L Wroclawski; Fernando L A Fonseca; Rodolfo B dos Reis; Antônio C L Pompeo; Auro Del Giglio Journal: BMC Urol Date: 2010-05-19 Impact factor: 2.264
Authors: Gijsberta J van Londen; Matthew E Levy; Subashan Perera; Joel B Nelson; Susan L Greenspan Journal: Crit Rev Oncol Hematol Date: 2008-08-15 Impact factor: 6.312
Authors: Farhana Haseen; Liam J Murray; Chris R Cardwell; Joe M O'Sullivan; Marie M Cantwell Journal: J Cancer Surviv Date: 2010-01-21 Impact factor: 4.442