Junji Zhang1, Keng Shen, Jinghe Lang. 1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Abstract
OBJECTIVE: To determine the effect of chemotherapy on glucose metabolism in patients with malignant ovarian tumor. METHODS: The blood glucose assay and associated clinical materials of 375 cases with malignant ovarian tumor who received chemotherapy from January 1997 to December 2001 were analyzed retrospectively. RESULTS: Thirty-two cases (8.5%) had elevated fasting blood glucose after chemotherapy. Among them, 14 cases (3.7%) were diagnosed as diabetes mellitus, 9 cases (2.4%) were diagnosed as impaired glucose tolerance. Paclitaxel based chemotherapy seemed to have more opportunity to induce disorders of glucose metabolism than that in cisplatin based chemotherapy (P < 0.05), and this happened most frequently in 1 approximately 3 courses. CONCLUSION: Chemotherapy may induce disorders of glucose metabolism, which most frequently occurred in 1 approximately 3 courses, including impaired glucose tolerance or diabetes mellitus,especially in patients received paclitaxel chemotherapy.
OBJECTIVE: To determine the effect of chemotherapy on glucose metabolism in patients with malignant ovarian tumor. METHODS: The blood glucose assay and associated clinical materials of 375 cases with malignant ovarian tumor who received chemotherapy from January 1997 to December 2001 were analyzed retrospectively. RESULTS: Thirty-two cases (8.5%) had elevated fasting blood glucose after chemotherapy. Among them, 14 cases (3.7%) were diagnosed as diabetes mellitus, 9 cases (2.4%) were diagnosed as impaired glucose tolerance. Paclitaxel based chemotherapy seemed to have more opportunity to induce disorders of glucose metabolism than that in cisplatin based chemotherapy (P < 0.05), and this happened most frequently in 1 approximately 3 courses. CONCLUSION: Chemotherapy may induce disorders of glucose metabolism, which most frequently occurred in 1 approximately 3 courses, including impaired glucose tolerance or diabetes mellitus,especially in patients received paclitaxel chemotherapy.