Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract.

Methanol extract of Leucas lavandulaefolia (LLFE) was subjected to antipyretic evaluation with yeast-induced pyrexia in rats. A yeast suspension (10 mL/kg, s.c.) increased the rectal temperature 19 h after administration. The extract at doses of 100, 200, 400 mg/kg (i.p.) produced significant dose dependent lowering of body temperature in yeast-provoked elevation of body temperature in rats. The antipyretic effect produced was comparable to that of a standard antipyretic drug, paracetamol. Copyright 2002 John Wiley & Sons, Ltd.