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Literature DB >> 12410494

Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.

C Bradley Hare¹, Mai P Vu, Carl Grunfeld, Harry W Lampiris.

Abstract

We report the first death associated with rhabdomyolysis in a patient treated with a statin and a protease inhibitor, which produced a significant drug-drug interaction.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2002 PMID： 12410494 DOI： 10.1086/344179

Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079

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Cited

18 in total

1. Prediction and in vitro evaluation of selected protease inhibitor antiviral drugs as inhibitors of carboxylesterase 1: a potential source of drug-drug interactions.

Authors: Jenna A Rhoades; Yuri K Peterson; Hao-Jie Zhu; David I Appel; Charles A Peloquin; John S Markowitz
Journal: Pharm Res Date: 2011-12-09 Impact factor: 4.200

2. Simvastatin co-prescribed with protease inhibitors despite dangerous drug interactions.

Authors: Katherine M Coyne; Marta Boffito; Nick Theobald; David Asboe
Journal: Sex Transm Infect Date: 2007-10 Impact factor: 3.519

Review 3. A Review of the Toxicity of HIV Medications II: Interactions with Drugs and Complementary and Alternative Medicine Products.

Authors: Andrew Stolbach; Karolina Paziana; Harry Heverling; Paul Pham
Journal: J Med Toxicol Date: 2015-09

Review 4. Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs.

Authors: Joel da Cunha; Luciana Morganti Ferreira Maselli; Ana Carolina Bassi Stern; Celso Spada; Sérgio Paulo Bydlowski
Journal: World J Virol Date: 2015-05-12

Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.

1. Prediction and in vitro evaluation of selected protease inhibitor antiviral drugs as inhibitors of carboxylesterase 1: a potential source of drug-drug interactions.

2. Simvastatin co-prescribed with protease inhibitors despite dangerous drug interactions.

Review 3. A Review of the Toxicity of HIV Medications II: Interactions with Drugs and Complementary and Alternative Medicine Products.

Review 4. Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs.

Review 5. Acute coronary syndrome in HIV patients: from pathophysiology to clinical practice.

Review 6. Drug-drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors.

7. Lack of pharmacokinetic interactions between pitavastatin and efavirenz or darunavir/ritonavir.

Review 8. Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.

9. Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.

10. The Relationship Between HIV Infection and Cardiovascular Disease.