Literature DB >> 12410091

Pathogenesis of fibrosis: role of TGF-beta and CTGF.

Hironobu Ihn1.   

Abstract

Transforming growth factor (TGF)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis. TGF-beta is believed to be a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathologic states such as systemic sclerosis. TGF-beta is known to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Connective tissue growth factor (CTGF), which is induced by TGF-beta, has been reported to mediate stimulatory actions of TGF-beta ECM synthesis. This review focuses on the possible role of TGF-beta and CTGF in the pathogenesis of fibrosis.

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Year:  2002        PMID： 12410091     DOI： 10.1097/00002281-200211000-00009

Source DB:  PubMed          Journal:  Curr Opin Rheumatol        ISSN： 1040-8711            Impact factor:   5.006


  99 in total

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5.  Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms.

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8.  Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.

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Review 9.  Idiopathic palmar fasciitis with polyarthritis syndrome.

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10.  Down-regulation of transforming growth factor beta-2 expression is associated with the reduction of cyclosporin induced gingival overgrowth in rats treated with roxithromycin: an experimental study.

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