| Literature DB >> 12409140 |
Zhao-Ning Ji1, Wen-Cai Ye, Guo-Ging Liu, W L Wendy Hsiao.
Abstract
23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were determined by flow cytometry analysis. A PCR-based telomeric repeat amplification protocol assay was used to detect telomerase activity. Results showed that 23-hydroxybetulinic acid induced growth arrest and apoptotic cell death in HL-60 cells. The apoptotic events were associated with concurrent down-regulation of bcl-2 and the telomerase activity. Our data suggest that 23-hydroxybetulinic acid may be a potential cytotoxic agent for treatment of cancer.Entities:
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Year: 2002 PMID： 12409140 DOI： 10.1016/s0024-3205(02)02176-8
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037