Literature DB >> 12408944

Hardy-Weinberg equilibrium diagnostics.

André Rogatko1, Michael J Slifker, James S Babb.   

Abstract

We propose two diagnostics for the statistical assessment of Hardy-Weinberg equilibrium. One diagnostic is the posterior probability of the complement of the smallest highest posterior density credible region that includes points in the parameter space consistent with the hypothesis of equilibrium. The null hypothesis of equilibrium is to be rejected if this probability is less than a pre-selected critical level. The second diagnostic is the proportion of the parameter space occupied by the highest posterior density credible region associated with the critical level. These Bayesian diagnostics can be interpreted as analogues of the classical types I and II error probabilities. They are broadly applicable: they can be computed for any hypothesis test, using samples of any size generated according to any distribution.

Mesh:

Year:  2002        PMID: 12408944     DOI: 10.1006/tpbi.2002.1613

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  3 in total

1.  Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia.

Authors:  S Numata; S Ueno; J Iga; K Yamauchi; S Hongwei; S Kinouchi; S Shibuya-Tayoshi; S Tayoshi; H Aki; S Sumitani; M Itakura; T Ohmori
Journal:  J Neural Transm (Vienna)       Date:  2006-08-08       Impact factor: 3.575

2.  HW_TEST, a program for comprehensive HARDY-WEINBERG equilibrium testing.

Authors:  Fernando Azenha Bautzer Santos; Renan Barbosa Lemes; Paulo Alberto Otto
Journal:  Genet Mol Biol       Date:  2020-05-11       Impact factor: 1.771

3.  Testing allele homogeneity: the problem of nested hypotheses.

Authors:  Rafael Izbicki; Victor Fossaluza; Ana Gabriela Hounie; Eduardo Yoshio Nakano; Carlos Alberto de Bragança Pereira
Journal:  BMC Genet       Date:  2012-11-23       Impact factor: 2.797

  3 in total

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