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Literature DB >> 12408813

Duplicating dangerously: linking centrosome duplication and aneuploidy.

Abstract

Centrosomes are far more fascinating than the first explorers of this organelle a century ago could ever have imagined. Recent evidence indicates that deregulation of centrosome duplication affects centrosome number and promotes aneuploidy, features characteristic of human tumors.

Entities: Disease Species

Mesh：

Substances：
Cell Cycle Proteins

Year: 2002 PMID： 12408813 DOI： 10.1016/s1097-2765(02)00654-8

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

36 in total

Review 1. Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1.

Authors: Anuradha S Budhu; Xin W Wang
Journal: Cell Cycle Date: 2005-11-20 Impact factor: 4.534

2. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

Authors: Thomas D Barber; Kirk McManus; Karen W Y Yuen; Marcelo Reis; Giovanni Parmigiani; Dong Shen; Irene Barrett; Yasaman Nouhi; Forrest Spencer; Sanford Markowitz; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Philip Hieter
Journal: Proc Natl Acad Sci U S A Date: 2008-02-25 Impact factor: 11.205

3. Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance.

Authors: Wallace F Marshall
Journal: Biophys J Date: 2007-05-11 Impact factor: 4.033

4. RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication.

Authors: A Duensing; Y Liu; N Spardy; K Bartoli; M Tseng; J-A Kwon; X Teng; S Duensing
Journal: Oncogene Date: 2006-07-03 Impact factor: 9.867

10. Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells.

Authors: Carolin Manthey; Demissew S Mern; Anja Gutmann; Anne J Zielinski; Corinna Herz; Silke Lassmann; Jens Hasskarl
Journal: BMC Cell Biol Date: 2010-01-14 Impact factor: 4.241

Duplicating dangerously: linking centrosome duplication and aneuploidy.

Review 1. Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1.

2. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

3. Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance.

4. RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication.

5. Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer.

Review 6. Centrioles: active players or passengers during mitosis?

7. Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes.

8. Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.

9. Mps1 as a link between centrosomes and genomic instability.

10. Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells.