| Literature DB >> 12408812 |
Abstract
Many bacterial pathogens turn on virulence genes at host body temperature. In the September 6, 2002, issue of Cell, Johansson et al. show that the Listeria monocytogenes thermosensor is an RNA structure in the 5' untranslated region of the mRNA for the virulence-activating transcription factor PrfA. The stem-loop structure blocks translation initiation at 30 degrees C but melts away at 37 degrees C.Entities:
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Year: 2002 PMID： 12408812 DOI： 10.1016/s1097-2765(02)00661-5
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970