| Literature DB >> 12408678 |
Yoshitaka Kumon1, Yuh Nakauchi, Tadashi Suehiro, Tomoko Shiinoki, Noriyasu Tanimoto, Mari Inoue, Toshihiro Nakamura, Kozo Hashimoto, Jean D Sipe.
Abstract
The expression of paraoxonase1 (PON1) during inflammation has been investigated in vitro. The alteration of steady state PON1 mRNA in HepG2 cells by interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), was investigated relative to acute-phase serum amyloid A (A-SAA) mRNA. PON1 mRNA expression by HepG2 cells was decreased within three hours of stimulation by IL-1beta or TNF-alpha. Relative to PON1 mRNA expression, the pattern of steady state A-SAA mRNA expression was altered reciprocally and inversely by IL-1beta. These findings suggested that the decrease in serum PON activity after abdominal surgery in our previous clinical study may be ascribed to a decrease in steady state PON1 mRNA expression by liver with proinflammatory cytokines.Entities:
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Year: 2002 PMID： 12408678 DOI： 10.3109/13506120209114817
Source DB: PubMed Journal: Amyloid ISSN： 1350-6129 Impact factor: 7.141